Mechanism of interaction of monovalent ions with phosphatidylcholine lipid membranes.

Vacha R, Jurkiewicz P, Petrov M, Berkowitz ML, Böckmann R, Barucha-Kraszewska J, Hof M, Jungwirth P (2010)

Publication Language: English

Publication Status: Published

Publication Type: Journal article

Publication year: 2010

Journal

Journal of Physical Chemistry B American Chemical Society

Publisher: American Chemical Society

Book Volume: 114

Pages Range: 9504-9

Volume: 114

Issue: 29

Journal Issue: 29

DOI: 10.1021/jp102389k

Abstract

Interactions of different anions with phospholipid membranes in aqueous salt solutions were investigated by molecular dynamics simulations and fluorescence solvent relaxation measurements. Both approaches indicate that the anion-membrane interaction increases with the size and softness of the anion. Calculations show that iodide exhibits a genuine affinity for the membrane, which is due to its pairing with the choline group and its propensity for the nonpolar region of the acyl chains, the latter being enhanced in polarizable calculations showing that the iodide number density profile is expanded toward the glycerol level. Solvent relaxation measurements using Laurdan confirm the influence of large soft ions on the membrane organization at the glycerol level. In contrast, chloride exhibits a peak at the membrane surface only in the presence of a surface-attracted cation, such as sodium but not potassium, suggesting that this behavior is merely a counterion effect.

Authors with CRIS profile

Rainer Böckmann Professur für Computational Biology

Involved external institutions

Academy of Sciences of the Czech Republic (ASCR) / Akademie věd České republiky (AVČR) CZ Czech Republic (CZ) University of North Carolina at Chapel Hill US United States (USA) (US)

How to cite

APA:

Vacha, R., Jurkiewicz, P., Petrov, M., Berkowitz, M.L., Böckmann, R., Barucha-Kraszewska, J.,... Jungwirth, P. (2010). Mechanism of interaction of monovalent ions with phosphatidylcholine lipid membranes. Journal of Physical Chemistry B, 114(29), 9504-9. https://doi.org/10.1021/jp102389k

MLA:

Vacha, Robert, et al. "Mechanism of interaction of monovalent ions with phosphatidylcholine lipid membranes." Journal of Physical Chemistry B 114.29 (2010): 9504-9.

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