Older patients with inoperable non-small cell lung cancer: long-term survival after concurrent chemoradiotherapy
Semrau S, Zettl H, Hildebrandt G, Klautke G, Fietkau R (2014)
Publication Type: Journal article
Publication year: 2014
Journal
Publisher: Springer Verlag (Germany)
Book Volume: 190
Pages Range: 1125-32
Journal Issue: 12
DOI: 10.1007/s00066-014-0710-5
Abstract
Considering the various comorbidities associated with aging, the feasibility and usefulness of concurrent chemoradiotherapy (CRT) in older patients with inoperable non-small cell lung cancer (NSCLC) is a controversial issue. Here, we compared the feasibility of CRT and the effects of various comorbidities on the prognosis of a minimally selected population of inoperable NSCLC patients aged 60-77 years.The study comprised 161 patients with inoperable NSCLC who received CRT with a target radiation dose greater than 60 Gy and platinum-based chemotherapy from 1998 to 2007. The total population included 69 patients aged 60-69 years and 53 aged 70-77 years. These two age cohorts were included in the study with a follow-up of a median 14.5 months.The two groups showed no differences in long-term survival, as reflected by the 5-year survival rates of 13.0 ± 4.1 % (60- to 69-year-olds) and 14.4 ± 4.9 % (70- to 77-year-olds). During the treatment phase, the groups were comparable in terms of toxicity and the feasibility of chemotherapy. Compared to patients in their 60s, the septuagenarians had more pulmonary comorbidities (p = 0.02), diabetes mellitus (p = 0.04), cardiac comorbidities (p = 0.08), and previous cancer disease (p = 0.08) that exerted a negative effect on survival. In patients without comorbidities, there were no differences between the age groups.Age is not a contraindication for concurrent CRT per se, because elderly patients do not have a worse long-term prognosis than younger seniors. However, "elderly patients" (>= 70-77 years) have more concomitant diseases associated with shorter survival than "moderately aged patients" (>= 60-69 years).
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Germany (DE)How to cite
APA:
Semrau, S., Zettl, H., Hildebrandt, G., Klautke, G., & Fietkau, R. (2014). Older patients with inoperable non-small cell lung cancer: long-term survival after concurrent chemoradiotherapy. Strahlentherapie und Onkologie, 190(12), 1125-32. https://doi.org/10.1007/s00066-014-0710-5
MLA:
Semrau, Sabine, et al. "Older patients with inoperable non-small cell lung cancer: long-term survival after concurrent chemoradiotherapy." Strahlentherapie und Onkologie 190.12 (2014): 1125-32.
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