ON and OFF electroretinography and contrast sensitivity in Duchenne muscular dystrophy

Salgueiro Barboni MT, Nagy BV, De Araujo Moura AL, Damico FM, Da Costa MF, Kremers J, Ventura DF (2013)

Publication Type: Journal article, Original article

Publication year: 2013

Journal

Investigative Ophthalmology & Visual Science Association for Research in Vision and Ophthalmology (ARVO)

Book Volume: 54

Pages Range: 3195-204

Journal Issue: 5

DOI: 10.1167/iovs.13-11700

Abstract

The study investigated possible asymmetric dysfunction of the ON and OFF visual mechanisms in DMD (Duchenne muscular dystrophy) patients associated with specific genetic alterations. Methods: nineteen DMD patients and 7 heterozygous dmd carriers were tested, as well as 19 age-matched controls.Full-field ergs were recorded using mesopic (1 cd/m(2)) and photopic (250 cd/m(2)) sawtooth luminance modulations as stimuli: rapid increase and ramping decrease (to isolate ON responses) or rapid decrease and ramping increase (for OFF responses). In addition, a psychophysical study comprised contrast sensitivity tests using two checkerboard stimuli at either higher (ON) or lower (OFF) luminance relative to the background: 0.3 cycles per degree (cpd) presented for 33 ms (low spatial frequency, short duration) and 2 cpd presented for 1500 ms (high spatial frequency, long duration).A significant ERG amplitude reduction, relative to controls, was detected in the DMD patients in the mesopic positive peaks for both ON and OFF stimuli, as well as for the photopic ON stimulus (P < 0.05). Contrast sensitivity was significantly lower in the DMD patients (P < 0.05) relative to controls for the ON stimuli. Neither the ERG nor the contrast sensitivities were altered in the carriers.This study suggests that there are ON and OFF ERG alterations when both rods and cones contribute to the ERG responses in DMD patients. When only cones are activated there is an asymmetrical ERG alteration, also revealed by the contrast sensitivity measurements.

Authors with CRIS profile

Jan Kremers Professur für Experimentelle Augenheilkunde

Involved external institutions

University of São Paulo / Universidade de São Paulo (USP) BR Brazil (BR)

How to cite

APA:

Salgueiro Barboni, M.T., Nagy, B.V., De Araujo Moura, A.L., Damico, F.M., Da Costa, M.F., Kremers, J., & Ventura, D.F. (2013). ON and OFF electroretinography and contrast sensitivity in Duchenne muscular dystrophy. Investigative Ophthalmology & Visual Science, 54(5), 3195-204. https://doi.org/10.1167/iovs.13-11700

MLA:

Salgueiro Barboni, Mirella Telles, et al. "ON and OFF electroretinography and contrast sensitivity in Duchenne muscular dystrophy." Investigative Ophthalmology & Visual Science 54.5 (2013): 3195-204.

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