Clinical Course of an Early Childhood-Onset Granulomatosis with Polyangiitis
Krasselt M, Pierer M, Amann KU, Bachmann A, Lindner TH (2017)
Publication Type: Journal article
Publication year: 2017
Journal
Book Volume: 142
Pages Range: 904-908
Journal Issue: 12
Abstract
History A 26-year-old male patient presented with an eight-week history of unspecific symptoms such as weight loss and fever. Besides, he also suffered from haemoptysis, cough, and arthralgia. Since the age of twelve years, the patient has been treated for Wegner's granulomatosis. At the age of 20 years he received a kidney transplant which failed only four years later. Investigations The relapse we clinically suspected was confirmed by CT scan showing bilateral pulmonary manifestations. Moreover, we found highly positive antibodies against proteinase 3. Treatment and course After an induction therapy using Glucocorticoids and Rituximab, accompanied by plasmapheresis, the patient's clinical condition showed a marked improvement. We were able to discharge him continuing the treatment in an outpatient setting. Conclusion Childhood-onset GPA is a life-threatening disease and often characterized by recurring relapses as well as a significantly reduced quality of life for the patient.
Authors with CRIS profile
Involved external institutions
Germany (DE)How to cite
APA:
Krasselt, M., Pierer, M., Amann, K.U., Bachmann, A., & Lindner, T.H. (2017). Clinical Course of an Early Childhood-Onset Granulomatosis with Polyangiitis. Deutsche Medizinische Wochenschrift, 142(12), 904-908. https://doi.org/10.1055/s-0043-101977
MLA:
Krasselt, Marco, et al. "Clinical Course of an Early Childhood-Onset Granulomatosis with Polyangiitis." Deutsche Medizinische Wochenschrift 142.12 (2017): 904-908.
BibTeX: Download