VI-Generierung Impfstoffkan gegen BoDV-1: Generation of recombinant vaccine candidates against BoDV-1
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.01.2026
End date : 31.12.2026
Project details
Scientific Abstract
Borna Disease Virus 1 (BoDV-1) causes fatal encephalitis in humans. This project aims to generate recombinant variants of the glycoprotein G via structure-guided vaccine design. The G variants will be conjugated to the surface of liposomes that incorporate biomolecular adjuvants to boost immunogenicity. Optionally, we aim to mimic a live-attenuated vaccine by additional encapsulation of viral structural proteins. The BoDV-1 liposomes would be used in future studies with antibody-humanized mice.
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Institute of Clinical and Molecular Virology
