P166: Role of C-terminal Binding Protein 1 (CTBP1) in Hippocampal Energetics
FAU own research funding: EFI / IZKF / EAM ...
Start date : 16.11.2024
End date : 30.11.2025
Project details
Scientific Abstract
Mutations in CTBP1 cause rare neurodevelopmental syndrome HADDTS. I have shown that CTBP1 controls hippocampal energy metabolism and protects synaptic transmission from metabolic stress Notably, deletion in glia and/or neurons had distinct effects. Here, we will investigate the role of CTBP1 in neuron-glia metabolic coupling necessary for energetic and functional homeostasis in brain. The results will provide new rational basis for treatment of HADDTS.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Department of Psychiatry and Psychotherapy
