P104: Combined inhibition of Hedgehog- and AP1-signaling as novel therapeutic strategy in fibrotic disease
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.08.2022
End date : 31.07.2023
Project details
Scientific Abstract
Systemic Sclerosis (SSc) is a fibrosing disorder with a high lethality. We demonstrate that Hedgehog-Signaling and AP1-signals mutually amplify in fibrosing disorders. We plan to analyze the effects of the combined inhibition of both signaling pathways on the evolvement of fibrosis and the mechanisms of mutual amplification. We will investigate the association of combined upregulation of both pathways with clinical patient data and investigate potential prognostic implications.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Department of Medicine 3 – Rheumatology and Immunology
Medizinische Fakultät
