IZKF-J82 (M3): Dynamic changes in O-GlcNAcylation regulate osteoclast differentiation and inflammation-induced bone loss

FAU own research funding: EFI / IZKF / EAM ...


Start date : 01.01.2020

End date : 31.12.2020

Project details

Scientific Abstract

We demonstrate that dynamic changes in the levels of O-GlcNAcylation are critically required for osteoclastogenesis. Inhibition of this dynamic regulation prevents osteoclast differentiation and ameliorates local and systemic bone loss in experimental arthritis. We now aim to further characterize the signaling pathways regulated by O-GlcNAcylation in inflammatory and non-inflammatory bone loss and to validate targeted modulation of O-GlcNAcylation as a therapeutic option for aberrant bone loss.

Involved:

Georg Schett Project Member Max Kraner Project Member Jörg Distler Project Member

Contributing FAU Organisations:

Lehrstuhl für Biochemie Interdisziplinäres Zentrum für Klinische Forschung (IZKF) Department of Medicine 3 – Rheumatology and Immunology Professur für Molekulare Mechanismen der Organfibrose Lehrstuhl für Innere Medizin III Medizinische Fakultät

Research Areas

Microscope SVG Junior Projects Field of Research