P152-OA: STAT2-mediated control of type I IFN signaling in colorectal tumorigenesis
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.05.2024
End date : 31.08.2024
Project details
Scientific Abstract
Colorectal cancer is the second leading cause of cancer-related deaths in developed countries. Our preliminary results underscore the significant role of the type I IFN-STAT2 pathway in driving necroptotic epithelial cell death, colonic inflammation, colorectal cancer progression, and resistance to anti-cancer drugs. We aim to elucidate the detailed mechanisms behind these findings. This understanding is crucial for developing innovative strategies for managing colorectal cancer in patients.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology
Medizinische Fakultät
