P068(Biochemie u.Pathobioch.): Impact of the cellular microenvironment of brain organoids on pericyte-to-neuron direct reprogramming
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.06.2020
End date : 31.05.2021
Project details
Scientific Abstract
We have shown that pericytes derived from the adult human brain can be reprogrammed into induced neurons (iNs) by overexpressing the transcription factors Ascl1 and Sox2. A major challenge to further assess functionality of iNs is posed by the lack of human model systems to study whether iNs adopt properties of human bona fide neurons. In the present proposal we therefore aim at assessing the impact of the cellular microenvironment provided by brain organoids on the reprogramming outcome.
Involved:
Contributing FAU Organisations:
Professur für Biochemie und Molekulare Neurowissenschaften
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Medizinische Fakultät
