P080: Impact of microbial tryptophan metabolites on intestinal permeability and rheumatoid arthritis
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.06.2021
End date : 31.05.2022
Project details
Scientific Abstract
Intestinal barrier integrity is an important checkpoint in translating autoimmunity to inflammation in rheumatoid arthritis (RA). Microbial metabolites of tryptophan were shown to reduce intestinal permeability and inflammation. However, it is unknown if this translates to a favourable impact on RA. Furthermore, it is unknown how the metabolites are intestinally resorbed. These questions should be adressed in cell models of intestinal epithelium and in human serum samples.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Lehrstuhl für Klinische Pharmakologie und Klinische Toxikologie
Medizinische Fakultät
