P141: Basophils in skin-mediated sensitization for allergic lung inflammation
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.10.2023
End date : 30.09.2024
Extension date: 31.03.2025
Project details
Scientific Abstract
A disturbed skin barrier allows for sensitization to skin-encountered allergen. Upon lung challenge with the same allergen stronger lung inflammation occurs. Preliminary data shows that basophils drive skin-mediated, allergen-specific antibody formation and we want to analyze their impact on barrier integrity and aspects of the antibody repertoire. We further plan lung-challenge of sensitized basophil deficient mice to determine functional relevance potentially critical for asthma development.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Department of Infection Biology
Medizinische Fakultät
