Third Party Funds Group - Sub project
Acronym: SFB/TRR 241
Start date : 01.07.2022
End date : 30.06.2026
Extension date: 30.06.2030
Website: https://www.transregio241.de/
Therapy-refractory subgroups of patients suffering from IBD often feature deep ulcerations and neutrophil granulocyte-related molecular signatures. We propose that the interplay between neutrophils and wound-associated intestinal epithelial cells determines successful epithelial restitution and will shed light on this conflicted intercellular crosstalk. We focus on how wound-associated epithelia are imprinted by neutrophils in the ulcer microenvironment and which protective mechanisms are used by these specialized cells in order to shape the innate immune response and support mucosal healing in IBD-related ulcers.