P120: Enteric glial cell activation and function in gut inflammation as a function of immune-derived cytokines
Third party funded individual grant
Start date : 01.07.2023
End date : 30.06.2024
Project details
Scientific Abstract
The role of the enteric glial cells (EGCs) in regulating mucosal immune homeostasis is largely unknown. We propose that EGC activation is tunable by cytokines and activated EGCs can shape gut immunity. Isolation, ex vivo activation, and submucosal transplantation of EGC will reveal their immunomodulatory capacity. Insights gained will reveal new avenues to curb chronic inflammation in disorders such as IBD.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology
Medizinische Fakultät
