P096: Orphan nuclear receptor DAX-1 mediates fibroblast activation and skin fibrosis
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.01.2022
End date : 31.08.2022
Project details
Scientific Abstract
SSc is the systemic rheumatic disease with the highest disease-related mortality. We identified DAX-1 as a mediator of fibroblast activation. We showed that DAX-1 is upregulated in fibrotic skin and that knockdown of Dax-1 ameliorates skin fibrosis. We plan to further characterize the mechanism of DAX-1 upregulation and study its potential transcriptional role in fibroblast activation as well as its potential antifibrotic role in 3D skin models and precision cut tissue slices from SSc skin.
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Department of Medicine 3 – Rheumatology and Immunology
Medizinische Fakultät
