P090: Functional analysis of the transcription factor NFATc3 in the promotion of intestinal inflammation
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.02.2022
End date : 31.01.2023
Extension date: 31.07.2023
Project details
Scientific Abstract
The transcription factor NFATc3 is important for regulating T cells. Patients with inflammatory bowel disease had high numbers of NFATc3+ cells in the lamina propria indicating an involvement of NFATc3 in mucosal inflammation. To investigate NFATc3 and colitis we will use specific knockout mice in experimental colitis models and analyse its molecular function. The results should clarify the role of NFATc3 in intestinal inflammation and provide a basis for NFATc3 as a new therapeutic concept.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology
Medizinische Fakultät
