J095: The role of acetyltransferase Tip60 in the developing PNS and peripheral neuropathies
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.01.2022
End date : 30.06.2024
Extension date: 30.09.2025
Project details
Scientific Abstract
Proper Schwann cell development and myelination are essential for a functional peripheral nervous system and regulated by networks of chromatin modifiers and transcription factors. Here I plan to study the role of the acetyltransferase Tip60 as part of the Tip60/Ep400 chromatin remodeling complex in lineage progression and myelination by characterizing its target genes and interaction with transcription factor Sox10. Results may help to better understand peripheral neuropathies.
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Lehrstuhl für Biochemie und Pathobiochemie
Medizinische Fakultät
