F8 (Zell. und Mol. Physiologie): Electrophysiological analysis and molecular modeling of the polycystin-2 ion channel mutated in ADPKD
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.02.2020
End date : 31.07.2022
Extension date: 31.01.2023
Project details
Scientific Abstract
In about 15 % of affected patients ADPKD (autosomal dominant polycystic kidney disease) is caused by mutations in the PKD2 gene coding polycystin-2 (PC2). Altered ion channel properties of PC2 may contribute to the pathophysiology of ADPKD. This project uses a novel experimental strategy to study the electrophysiological properties of PC2 and mutant PC2 channels in combination with molecular modelling. Its aim is to improve our understanding of PC2 ion channel function in health and disease.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Lehrstuhl für Physiologie (Vegetative Physiologie)
Medizinische Fakultät
