P077: Modulation of human osteoclast differentiation and function in healthy- and RA-patients by soluble CD83
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.07.2021
End date : 30.06.2022
Project details
Scientific Abstract
Osteoclasts are the bone-resorbing cells of the body, which lead to severe damage of the musculoskeletal system under pathological conditions (such as RA). Treatment with soluble CD83 inhibited bone destruction in the murine arthritis model. Aim of this proposal is the translation of the murine data into the human system, which repre-sents the next important step towards future therapeutic applications.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Department of Immune Modulation
Medizinische Fakultät
