J096: Role of amyloidogenic B-secretases as regulators of the tumor-stroma crosstalk in colorectal cancer
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.10.2021
End date : 31.03.2024
Extension date: 30.09.2024
Project details
Scientific Abstract
The ?-secretases (Bace1 and Bace2) are proteases involved in the pathogenesis of Alzheimers disease (AD). However, Bace1/2 can be found in tissues other than the brain, suggesting that their role goes well beyond AD. Interestingly, our preliminary data reveal that the expression of Bace1/2 is modulated in response to intestinal inflammation and during cancer development. We hypothesize that the ?-secretases might have regulatory functions in the gut and the pathophysiology of colorectal cancer
Involved:
Contributing FAU Organisations:
Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Medizinische Fakultät
