Unknown functions of Osteocyte Death (ODE)

The ODE project will provide new understanding about the sensitive balance of bone homeostasis, and how stress factors in bone such as inflammation and reduced vascularization influence the viability of osteocytes. We will decipher in detail which impact the death of osteocytes has on the bone environment and bone strength and how we can avoid this negative influence. On a broader scale, we can use the gained knowledge to better understand the pathogenesis of bone loss and discover potential new pathways that might be targeted in the future to prevent bone loss from happening.