A088: Regulatory interaction btw. cyclins and cytomegalovirus kinase pUL97: focus on pUL97 drug resistance mutations

FAU own research funding: EFI / IZKF / EAM ...


Start date : 01.02.2020

End date : 31.07.2022

Extension date: 31.07.2023

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Cytomegalovirus cyclin-dependent kinase ortholog vCDK/pUL97 undergoes regulatory interaction with human cyclin H and CDK7 to codetermine viral replication efficiency (2023) Schütz M, Wangen C, Sommerer M, Kögler M, Eickhoff J, Degenhart C, Klebl B, et al. Journal article The Interactive Complex between Cytomegalovirus Kinase vCDK/pUL97 and Host Factors CDK7-Cyclin H Determines Individual Patterns of Transcription in Infected Cells. (2023) Schütz M, Cordsmeier A, Wangen C, Horn A, Wyler E, Enßer A, Sticht H, Marschall M Journal article Highly Conserved Interaction Profiles between Clinically Relevant Mutants of the Cytomegalovirus CDK-like Kinase pUL97 and Human Cyclins: Functional Significance of Cyclin H (2022) Schütz M, Müller R, Socher E, Wangen C, Full F, Wyler E, Wong DD, et al. Journal article Recombinant Human Cytomegalovirus Expressing an Analog-Sensitive Kinase pUL97 as Novel Tool for Functional Analyses (2022) Krämer N, Schütz M, Mato UG, Herhaus L, Marschall M, Zimmermann C Journal article Cyclin‐Dependent Kinases (CDKs) and the Human Cytomegalovirus‐Encoded CDK Ortholog pUL97 Represent Highly Attractive Targets for Synergistic Drug Combinations (2022) Wild M, Hahn F, Brückner N, Schütz M, Wangen C, Wagner S, Sommerer M, et al. Journal article Antiviral Strategies Using Natural Source-Derived Sulfated Polysaccharides in the Light of the COVID-19 Pandemic and Major Human Pathogenic Viruses (2022) Ray B, Ali I, Jana S, Mukherjee S, Pal S, Ray S, Schütz M, Marschall M Journal article A placental specific miRNA miR-517a-3p exerts anti-human cytomegalovirus activity (2021) Hamilton ST, Hahn F, Sonntag E, Marschall M, Rawlinson WD Journal article Functional Relevance of the Interaction between Human Cyclins and the Cytomegalovirus-Encoded CDK-Like Protein Kinase pUL97 (2021) Schütz M, Steingruber M, Socher E, Müller R, Wagner S, Kögel M, Sticht H, Marschall M Journal article, Original article Combinatorial drug treatments reveal promising anticytomegaloviral profiles for clinically relevant pharmaceutical kinase inhibitors (PKIs) (2021) Wild M, Kicuntod J, Seyler L, Wangen C, Bertzbach LD, Conradie AM, Kaufer BB, et al. Journal article Investigational Antiviral Therapy Models for the Prevention and Treatment of Congenital Cytomegalovirus Infection during Pregnancy (2021) Hamilton ST, Marschall M, Rawlinson WD Journal article
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