A076: Elucidating the regulation and function of Gasdermin C in intestinal infection and inflammation
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.02.2020
End date : 31.07.2022
Extension date: 31.01.2023
Project details
Scientific Abstract
We have discovered Gasdermin C as a protein strongly induced in the gut epithelium by IL-4 and IL-13. We can show that Gasdermin C is released by goblet cells into the mucous layer where it binds to bacteria. Further analyses implicate that Gasdermin C has a pore forming function and promotes anti-microbial defence. We plan to elucidate the regulation of Gasdermin C, its molecular mode of action and its functional impact in vivo.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Professur für Molekulare Gastroenterologie
Medizinische Fakultät
