IZKF-J65 (P2): Regulation of the t-system and associated proteins in cardiomyocytes by glucocorticoid receptor signaling

FAU own research funding: EFI / IZKF / EAM ...


Start date : 01.11.2017

End date : 31.10.2020


Project details

Scientific Abstract

The transverse tubular system (t-system) of ventricular cardiomyocytes is crucial for cardiac contractility. Stabilizing t-system structure is a target of therapy and prevention because the t-system depletes or structurally declines in heart failure. However, mechanisms of t-system regulation remain largely unknown. Our preliminary data suggest t-system regulation by corticoid receptor signaling. The proposed project shall identify underlying signaling pathways and associated proteins.

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