IZKF-J65 (P2): Regulation of the t-system and associated proteins in cardiomyocytes by glucocorticoid receptor signaling
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.11.2017
End date : 31.10.2020
Project details
Scientific Abstract
The transverse tubular system (t-system) of ventricular cardiomyocytes is crucial for cardiac contractility. Stabilizing t-system structure is a target of therapy and prevention because the t-system depletes or structurally declines in heart failure. However, mechanisms of t-system regulation remain largely unknown. Our preliminary data suggest t-system regulation by corticoid receptor signaling. The proposed project shall identify underlying signaling pathways and associated proteins.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Lehrstuhl für Physiologie (Vegetative Physiologie)
Medizinische Fakultät
