E31: Targeting impaired proteasomal degradation in neurodevelopmental disorders
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.01.2020
End date : 31.08.2021
Project details
Scientific Abstract
Neurodevelopmental disorders (NDDs) are extremely heterogeneous but converge on a number of common molecular processes. Treatment options are limited so far. We will focus on a subset of NDD associated genes/proteins which are involved in the ubiquitin-proteasome system. We will investigate if manipulation of proteasome activity by small molecules can ameliorate phenotypes in Drosophila and/or cell based model systems and thus will gain insights into potential interventional options.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Lehrstuhl für Humangenetik
Medizinische Fakultät
