Lehrstuhl für Pharmazeutische Chemie

PH-Dependent Conformational Switching of Amide Bonds from Full trans to Full cis and Vice Versa (2022) Thurston R, Zantop V, Park KS, Maid H, Seitz A, Heinrich M Journal article Development of disulfide-functionalized peptides covalently binding G protein-coupled receptors (2022) Einsiedel J, Schmidt M, Hübner H, Gmeiner P Journal article Development of a NanoBRET assay to validate inhibitors of Sirt2-mediated lysine deacetylation and defatty-acylation that block prostate cancer cell migration (2022) Vogelmann A, Schiedel M, Woessner N, Merz A, Herp D, Hammelmann S, Colcerasa A, et al. Journal article Structural insights into ligand recognition, activation, and signaling of the α2Aadrenergic receptor (2022) Xu J, Cao S, Hübner H, Weikert D, Chen G, Lu Q, Yuan D, et al. Journal article The crystal structure of the varicella-zoster Orf24-Orf27 nuclear egress complex spotlights multiple determinants of herpesvirus subfamily specificity (2022) Schweininger J, Kriegel M, Häge S, Conrad M, Alkhashrom S, Lösing J, Weiler S, et al. Journal article Comparison of Cellular Target Engagement Methods for the Tubulin Deacetylases Sirt2 and HDAC6: NanoBRET, CETSA, Tubulin Acetylation, and PROTACs (2022) Vogelmann A, Jung M, Hansen FK, Schiedel M Journal article, Review article A Chemical Biology Toolbox Targeting the Intracellular Binding Site of CCR9: Fluorescent Ligands, New Drug Leads and PROTACs (2022) Huber M, Toy L, Schmidt M, Vogt H, Budzinski J, Wiefhoff MFJ, Merten N, et al. Journal article A novel D-amino acid peptide with therapeutic potential (ISAD1) inhibits aggregation of neurotoxic disease-relevant mutant Tau and prevents Tau toxicity in vitro (2022) Aillaud I, Kaniyappan S, Chandupatla RR, Ramirez LM, Alkhashrom S, Eichler J, Horn A, et al. Journal article Analysis of hyperforin (St. John’s wort) action at TRPC6 channel leads to the development of a new class of antidepressant drugs (2022) El Hamdaoui Y, Zheng F, Fritz N, Ye L, Tran MA, Schwickert K, Schirmeister T, et al. Journal article Tunable Composition of Mixed Self-Assembled Shell-by-Shell Structures on Nanoparticle Surfaces (2022) Eigen A, Stiegler L, Gradl S, Schneider V, Wedler V, Gaß H, Müller L, et al. Journal article